Efectores de oomycetes fitopatogénicos: en la primera línea de ataque

Contenido principal del artículo

Javier Martínez Pacheco

Resumen

Los oomycetes son un grupo filogenéticamente distinto de microorganismos eucariotas que incluyen a algunos de los patógenos de plantas más dañinos. Los oomycetes logran la colonización de los tejidos vegetales modulando las defensas de las células del hospedero a través de un conjunto de proteínas efectoras o efectores. Se identifican dos clases generales de efectores de oomycetes fitopatogénicos: los efectores apoplásticos secretados en el espacio extracelular de las células vegetales y los citoplasmáticos, translocados hacia el interior de las células del hospedero. Comprender realmente cómo funcionan estos efectores y cuáles son sus roles precisos en los mecanismos de infección de los patógenos son desafíos importantes para los próximos años.

Detalles del artículo

Cómo citar
Efectores de oomycetes fitopatogénicos: en la primera línea de ataque. (2015). Fitosanidad, 19(3), 25-257. https://fitosanidad.edicionescervantes.com/index.php/fitosanidad/article/view/154
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Artículos de revisión

Cómo citar

Efectores de oomycetes fitopatogénicos: en la primera línea de ataque. (2015). Fitosanidad, 19(3), 25-257. https://fitosanidad.edicionescervantes.com/index.php/fitosanidad/article/view/154

Referencias

Birch, P.R.; A.P. Rehmany; L. Pritchard; S. Kamoun y J.L. Beynon: «Trafficking arms: oomycete effectors enter host plant cells», TRENDS in Microbiology 14 (1):8-11, Reino Unido, 2006.

Birch, P.R.; P.C. Boevink; E. M. Gilroy; I. Hein; L. Pritchard: S. C. Whisson: «Oomycete RXLR effcetors: delivery, functional redundancy and durable disease resistance», Current Opinion in Plant Biology, 11 (4):373-379, Reino Unido, 2008.

Blair, J.E.; M.D. Coffey; S-Y. Park; D.M. Geiser; S. Kang: «A multi-locus phylogeny for Phytophthora utilizing markers from complete genome sequences», Fungal Genet. Biol. 45 (3):266–277, Holanda, 2008.

Block, A.; G. Li; Z.Q. Fu; J.R. Alfano: «Phytopathogen type III effector weaponry and their plant targets», Curr. Opin. Plant Biol. 11 (4):396–403, Reino Unido, 2008.

Bos, J.I.; M. Armstrong; S.C. Whisson; T. Torto; M. Ochwo; P.R. Birch; S. Kamoun: «Intraspecific comparative genomics to identify avirulence genes from Phytophthora», New Phytol.159 (1):63-72, EE.UU, 2003.

Boutemy, L.S.; S.R. King; J. Win; R.K. Hughes; T.A. Clarke; T.M. Blumenschein; S. Kamoun; M.J. Banfield: «Structures of Phytophthora RXLR effector proteins: A conserved but adaptable fold underpins functional diversity», J. Biol. Chem. 286 (41):35834-35842, EE.UU, 2011.

Catanzariti, A.M.; P.N. Dodds; G.J. Lawrence; M.A. Ayliffe; J.G. Ellis: «Haustorially expressed secreted proteins from flax rust are highly enri- ched for avirulence elicitors», Plant Cell, 18 (1):243-256, EE.UU, 2006.

Damasceno, C.M.; J.G. Bishop; D.R. Ripoll; J. Win; S. Kamoun; J.K. Rose: «Structure of the glucanase inhibitor protein (GIP) family from Phytophthora species suggests coevolution with plant endo β-1, 3-glucanases», Mol. Plant–Microbe Interact. 21 (7):820-830, EE.UU, 2008.

De Jonge, R.; M. D. Bolton; B.P. Thomma: «How filamentous pathogens co-opt plants: the ins and outs of fungal effectors», Current Opinion in Plant Biology, 14 (4):400-406, Reino Unido, 2011.

Dou, D.; S.D. Kale; X. Wang; R.H. Jiang; N.A. Bruce; F.D. Arredondo; X. Zhang; B.M. Tyler: «RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery», Plant Cell, 20 (7):1930–1947, EE.UU, 2008.

Göker, M.; H. Voglmayer; A. Riethmuller; F. Oberwinkler: «How do obligate parasites evolve? A multi-gene phylogenetic analysis of downy mildews», Fungal Genet. Biol. 44 (2):105-122, Holanda, 2007.

Hardham, A.R.: «Cell biology of plant-oomycete interactions», Cellular Microbiology, 9 (1):31-39, EE.UU, 2007.

Hein, I.; E.M. Gilroy; M.R. Armstrong; P.R. Birch: «The zig-zag-zig in oomycete-plant interactions», Molecular Plant Pathology 10(4):547-562, EE.UU, 2009.

Jones, J.D.; J.L. Dangl: «The plant immune system», Nature, 444 (7117):323-329, Reino Unido, 2006.

Kamoun, S.; P. van West; A.J. de Jonge; K. de Groot; V. Vleeshouwers; F. Govers: «A gene encoding a protein elicitor of Phytophthora infestans is down-regulated during infection of potato», Mol. Plant Microbe. Interact.10 (1):13–20, EE.UU, 1997.

Kamoun, S.: «Molecular genetics of phytopathogenic oomycetes», Eukaryotic Cell, 2 (2):191-199, EE.UU, 2003.

Kamoun, S.: «A catalogue of the effector secretome of plant pathogenic oomycetes», Annu. Rev. Phytopathol. 44:41-60, EE.UU, 2006.

Kamoun, S.: «Groovy times: filamentous pathogen effectors revealed», Curr. Opin. Plant Biol. 10 (4):358-365, Reino Unido, 2007.

Kale, S.D.; B. Gu; D.G. Capelluto; D. Dou; E. Feldman; A. Rumore; F.D. Arredondo; R. Hanlon; I. Fudal; T. Rouxel: «External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells», Cell, 142 (6):981-983, EE.UU, 2010.

King, S.R.; H. McLellan; P.C. Boevink; M.R. Armstrong; T. Bukharova; O. Sukarta; J. Win; S. Kamoun; P.R.J. Birch; M.J. Banfield: «Phytophthora infestans RXLR effector PexRD2 interacts with host MAPKKKε to suppress plant immune signaling», The Plant Cell, 26 (3):1345-1359, EE.UU, 2014.

Latijnhouwers, M.; P. J. de Wit; F. Govers: «Oomycetes and fungi: similar weaponry to attack plants», TRENDS in Microbiology, 11(10):462- 469, Reino Unido, 2003.

Levesque, C.A.; W.A.M. de Cock: «Molecular phylogeny and taxonomy of the genus Pythium», Mycol. Res. 108 (12):1363-1383, Reino Unido, 2004.

Liu, Z.; J.I. Bos; M. Armstrong; S.C. Whisson; L. da Cunha; T. Torto-Alibo; J. Win; A. Avrova; F. Wright; P. Birch; S. Kamoun: «Patterns of diversifying selection in the phytotoxin-like scr74 gene family of Phytophthora infestans», Mol. Biol. Evol. 22 (3):659-672, Reino Unido, 2005.

Orsomando, G.; M. Lorenzi; N. Raffaelli; M. Dalla Rizza; B. Mezzetti; S. Ruggieri: «Phytotoxic protein PcF, purification, characterization, and cDNA sequencing of a novel hydroxyproline-containing factor secreted by the strawberry pathogen Phytophthora cactorum», J. Biol. Chem. 276 (3):21578-84, EE.UU, 2001.

Orsomando, G.; M. Lorenzi; E. Ferrari; C. de Chiara; A. Spisni; S. Ruggieri: «PcF protein from Phytophthora cactorum and its recombinant homologue elicit phenylalanine ammonia lyase activation in tomato», Cell. Mol. Life Sci. 60 (7):1470-76, Suiza, 2003.

Orsomando, G.; L. Brunetti; K. Pucci; B. Ruggeri; S. Ruggieri: «Comparative structural and functional characterization of putative effectors belonging to the PcF toxin family from Phytophthora spp.», Protein Science, 20 (12):2047-59, EE.UU, 2011.

Osman, H.; S. Vauthrin; V. Mikes, M.L. Milat; F. Panabieres; A. Marais; S. Brunie; B. Maume; M. Ponchet; J.-P. Blein: «Mediation of elicitin activity on tobacco is assumed by elicitin-sterol complexes», Mol. Biol. Cell, 12 (9):2825-34, EE.UU, 2001.

Panabieres, F.; J. Amselem; E. Galiana; J.Y. Le Berre: «Gene identification in the oomycete pathogen Phytophthora parasitica during in vitro vegetative growth through expressed sequence tags», Fungal Genet. Biol. 42 (7):611-623, Holanda, 2005.

Rehmany, A.P.; A. Gordon; L.E. Rose; R.L. Allen; M.R. Armstrong; S.C. Whisson; S. Kamoun; B.M. Tyler; P.R. Birch; J.L. Beynon: «Differential recognition of highly divergent downy mildew avirulence gene alleles by RPP1resistance genes from two Arabidopsis lines», Plant Cell, 17 (6):1839-1850, EE.UU, 2005.

Rose, J.K.; K.S. Ham; A.G. Darvill; P. Albersheim: «Molecular cloning and characterization of glucanase inhibitor proteins: coevolution of a counterdefense mechanism by plant pathogens», Plant Cell, 14 (4):1329-45, EE.UU, 2002.

Shan, W.; M. Cao; D. Leung; B.M. Tyler: «The Avr1b locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rps1b», Mol. Plant-Microbe Interact. 17(4):394-403, EE.UU, 2004.

Tian, M.; E. Huitema; L. da Cunha; T. Torto-Alalibo; S. Kamoun: «A Kazal like extracellular serine protease inhibitor from Phytophthora infestans targets the tomato pathogenesis-related protease P69B», J. Biol. Chem. 279 (4):26370-77, EE.UU, 2004.

Tian, M.; B. Benedetti; S. Kamoun: «A second Kazal-like protease inhibitor from Phytophthora infestans inhibits and interacts with the apoplastic pathogenesis-related protease P69B of tomato», Plant Physiol. 138 (3):1785-93, EE.UU, 2005.

Tian, M.; J. Win; J. Song; R. van der Hoorn; E. van der Knaap; S. Kamoun: «A Phytophthora infestans cystatin-like protein targets a novel tomato papain-like apoplastic protease», Plant Physiol. 143 (1):364- 377, EE.UU, 2007.

Torto, T.A.; S. Li; A. Styer; E. Huitema; A. Testa; N.A. Gow; P. van West; S. Kamoun: «EST mining and functional expression assays identify extracellular effector proteins from the plant pathogen Phytophthora», Genome Res. 13 (7):1675-1685, EE.UU, 2003.

Van Poppel, P.M.; J. Guo; P.J. van de Vondervoort; M.W. Jung; P.R. Birch; S.C. Whisson; F. Govers: «The Phytophthora infestans avirulence gene Avr4 encodes an RXLR-dEER effector», Mol. Plant-Microbe Interact. 21 (11):1460–1470, EE.UU, 2008.

Vauthrin, S.; V. Mikes; M.L. Milat; M. Ponchet; B. Maume; H. Osman; J.P. Blein: «Elicitins trap and transfer sterols from micelles, liposomes and plant plasma membranes», Biochim. Biophys. Acta, 1419 (2):335- 342, Holanda, 1999.

Vleeshouwers, V.G.; J.P. Rietman; P. Krenek; N. Champouret; C. Young; S.K. Oh; M. Wang; K. Bouwmeester; B. Vosman; R.G. Visser; E. Jacobsen; F. Govers; S. Kamoun; E.A. Van der Vossen: «Effector genomics accelerates discovery and functional profiling of potato disease resistance and Phytophthora infestans avirulence genes», PLoS ONE 3 (8):e2875, EE.UU, 2008.

Whisson, S.C.; P.C. Boevink; L. Moleleki; A.O. Avrova; J.G. Morales; E.M. Gilroy; M.R. Armstrong; S. Grouffaud; P. van West; S. Chapman; I. Hein; I.K. Toth; L. Pritchard; P.R. Birch: «A translocation signal for delivery of oomycete effector proteins into host plant cells», Nature, 450 (7166):115-119, Reino Unido, 2007.